点眼剤調製時におけるメンブランフィルターへの保存剤の吸着

抄録

The drug adsorption onto membrane filters (MF) from five kinds of eyedrops, atropine sulfate (AT), pilocarpine hydrochloride (PC), amphotericin B, dibekacin sulfate, and disodium edetate eyedrops during sterilization by filtration was investigated.
The principal ingredients in eyedrops were scarcely adsorbed to MF.In the preservatives, methyl and propyl parahydroxybenzoates in AT eyedrops were almost adsorbed to acetylcellulose MF, while benzalkonium chloride in PC eyedrops was almost adsorbed to MF made from mixed esters of cellulose, nitrocellulose or polyvinyliden fluoride. However, the adsorption of the preservatives can be fairly prevented by discarding the first part of the filtrate from eyedrops. From these results, when eyedrops containing above preservatives are sterilized by filtration, the use of MF on which adsorption was observed should be avoided, or the first part of the filtrate should be discarded.