抄録
In recent years, considerable attention has been focused on the subject of drug-drug interactions and the extensive drug informations concerning to these occurrences have been widely provided to health care professionals by many ways and means. However, there are few previous studies in the concrete guidelines for the prescribers to avoid significant harmful drug-drug interactions, the understanding of the guidelines by the prescribers, and the effects of the guidelines on the drug therapeutic regimens.
In this study, we issued a booklet for the drug information about new quinolones-metal cations interactions, which contained informations about how to avoid this drug-drug interactions. We also provided this booklet to all prescribers in our hospital by direct mail, and then we analyzed the effects of the booklet on the therapeutic alteration when the pharmacists detected this drug combinations in the prescriptions and recommended how to avoid the interaction. After the booklet was provided to the prescribers, the prescriptions with both drugs dramatically decreased and remained on a stable level. Furthermore, the 93% of the prescriptions containing both drugs are changed appropriately based on our recommendations. It is suggested that such information is very useful educational program for the health care professionals. In future, in order to support the rational drug therapeutic regimens by the prescribers, it is necessary to introduce the prescription checking system to the hospital.
