病院薬学
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
アンプルカットの方法と混入異物, およびガラス細片の動物におよぼす影響
山岡 桂子近森 温子阿部 由明所 安夫
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ジャーナル フリー

1976 年 2 巻 2 号 p. 111-116

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The number of glass particles arising in parenteral solution upon cutting of ampules was determined with use of 5-ml transparent and brown ampules. Cutting by “cracking” produced most satisfactory results of all methods devised. It was found as a result of the investigation by X-ray fluoroscopy that the solution contained in the ampules was almost completely free from particles from a file used for cutting. Mice injected intravenously into the tail with large amount of glass particles from ampule died of shock due to multiple pulmonary thrombosis. Tubercles caused by glass particles were observed in mice which survived the experiment without acute symptoms.
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© 一般社団法人 日本医療薬学会
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