Abstract
Small volume injections (SVIs) of NaHCO3 and heparin used in the United States have been reported to contain 60-70% of the maximum allowable number of particles described in United States Pharmacopeia (USP). We evaluated SVIs of KC1, CaCl2, NaHCO3 and heparin used in Japan using the electronic liquid-borne particle system. All SVIs examined showed remarkably lower numbers of particles than the limits described in USP. Even if several injections of each preparations are used together, the particle number may not exceed the USP limits.
