Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
Stability of Ascorbic Acid in Infusion Solution II
Effect of Some Metal Ions on the Producing Hydrogen Peroxide in Some Infusion Solutions added Otsuka MV and Multamin®
TADATAKA ISHIKAWAYOUKO SHIMENOMINORU IEKUSHITAMOTSU FUKUDA
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1995 Volume 21 Issue 3 Pages 203-214

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Abstract
In our previous report, we showed that producing hydrogen peroxide increased on standing in infusion solution to which was added multivitamins. Likewise, producing hydrogen peroxide increased on standing after mixing, increasing to 6.76 ppm with the combination of KN solution MG3 with Otsuka MV and to 6.65 ppm with the combination of Solita T®-4 with Multamin®. The Zn2+ and Mn2+ metal ions showed a little effect on the degradation of ascorbic acid (AsA) in spite of the shield, whereas Cu2+ remarkably promoted AsA degradation.
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© Japanese Society of Pharmaceutical Health Care and Sciences
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