抄録
A new double-chambered plastic bag for total parenteral nutrition (TPN) solution, PN-twin®, has become commercially available. One PN-twin® chamber termed layer I, contains dextrose and electrolytes while the other chamber, layer II, consists of amino acids. Test samples were prepared by adding vitamins and trace minerals to the mixtures of layers I and II solutions, and only to a layer 11 solution. The stabilities of vitamins A, B1, B2, B6, C, E, folic acid (FA) and K1 were studied under three different conditions: room temperature in a dark place, room temperature with light exposure, and cold in a dark place.
The residual rates of vitamins B2, C and K1 in the layers I and II solution mixture stored at room temperature with light exposure for 48 hours dropped to under 63%. With the addition of trace minerals into the test samples in a cold, dark place, the residual rate of vitamin C decreased significantly. Also, the residual rates of vitamin B1 in the layer II solution decreased rapidly. After storing at room temperature for 48 hours and/or in a cold, dark place for 7 days, the residual rates of vitamin B1 fell to below 6%. These findings suggested that the addition of vitamins to PN-twine® should be avoided before the two separate chambers and connected.
