抄録
We have developed prolonged release preparations of amikacin and epirubicin using microfibrous collagen (Aviten®) in combination with sodium alginate. The effect of sodium alginate on drug release from collagen was specially examined because an electrostatic interaction was expected bztween the carboxyl group of alginate and amino group of amikacin and epirubicin.
The release tests revealed that amikacin was rapidly released from the collagen, while its release was significantly delayed in the presence of sodium alginate in a concentration-dependent manner. Moreover, sodium alginate significantly retarded the release of epirubicin from collagen, despite the fact that epirubicin itself exhibited a strong affinity with collagen even in the absence of sodium alginate. Thus, it was shown that sodium alginate can be used to improve the controlled-release property of the microfibrous collagen preparation of certain drugs. Since the microfibrous collagen used is highly biocompatible, its preparations of amikacin and epirubicin with sodium alginate may be useful for local chemotherapy of bacterial infection and malignant tumor, respectively.
