Abstract
For the purpose of evahiating Kremezin as an antidote for acute drug poisoning, several grain sizes of Kremezin were determined by comparing both the adsorption capacities and the adsorption rate of phenobarbital and theophylline with a powdered activated carbon in vitro. The saturated adsorption capacities of these several Kremezin grain sizes to phenobarbital were 708.1mg/g (diameter <75μm, Type S), 696.1mg/g (75-90μm; Type M), 644.2 mg/g (150-180μm; Type L) and 596.2mg/g (200-400μm; opened Kremezin capsule). The saturated adsorption capacity of each Kremezin grain size was higher than that of powdered activated carbon (340.4mg/g). The adsorption rates of phenobarbital (300μg/ml) to Kremezin at 5 minutes were 82.0%(Type S), 75.1%(Type M), 43.8%(Type L) and 33.1%(opened capsule). These values were lower than that of powdered activated carbon (90.5%). However, the adsorption capacities of phenobarbital to Kremezin for 5 minutes were 417.1mg/g (Type S), 376.9 mg/g (Type M), 209.8mg/g (Type L) and 146.0mg/g (opened capsule). The adsorption capacities of Kremezin fine powder (Type S and M) were larger than that of a powdered activated carbon (264.2mg/g). The above data tended to be similar to those for theophylline. In conclusion, the fine powdered Kremezin seemed to be a more effective antidote for acute phenobarbital and theophylline poisoning than powdered activated carbon.
