抄録
The compatibility of irinotecan hydrochloride injection (Topotecin® injection) was studied on changes in external appearance, pH and contents of both irinotecan and admixed drugs following mixing with 24 kinds of other injections. Admixtures of irinotecan hydrochloride injection with each of the 24 kinds demonstrated neither a change in external appearance nor a change in pH over a 24 h period under the study conditions except for a slight change in pH in the admixtures of ATP for inj.(DAIICHI) ® or INOSIE®. In the case of the admixture with ATP inj.(DAIICHI) ®, MEYLON®, INOSIE®, NUTRASE for inj.(KYORIN) ® or Stronger Neo-Minophagen C®, the contents of irinotecan hydrochloride fell to 90% with in 3 h after mixing. In addition, after mixing URONASE ® 60, 000 U or LEUCON® INJECTION, their contents fell to 90% in 3 to 6 h.
The concentrations of closed lactone of irinotecan hydrochloride increased periodically and returned to the former state in 3 h when the alkaline solutions after mixing irinotecan hydrochloride injection with each ATP inj. (DAIICHI) ®, MEYLON ® and INOSIE ® were converted to pH 4.0. It has been established that the compatibility of irinotecan hydrochloride injection depends on the delactonization reaction of the drug.
This study suggests that admixing of irinotecan with high pH hydrochloride injection and with other injections of high pH value must be done very carefully. A possible drop in the contents of irinotecan would be predictable by checking pH described in the package inserts and by considering the buffering capacity of the admixed injections.
