高カロリー輸液無菌調製における品質管理
混合時のpH予測とエンドトキシンの測定条件
1999 年 25 巻 3 号 p. 323-329
詳細
1999 年 25 巻 3 号 p. 323-329
To ensure the quality of sterilized IVH preparations, we attempted to predict the pH of the admixture using Shoji's method (a method of for predicting incompatibility when admixing injections for infusion) and Iseki's method (a method for multiple admixture based on the acid-base equilibrium theory).
Furthermore, we also carefully measured the endotoxin levels in IVH.
A significant correration between the estimated pH and the measured pH (n=19) was observed in both Shoji's (r=0.9761) and Iseki's method (r=0.9849). In addition, the injected levels were determined by dilution with any sterile water and evaluated after recovering any added endotoxin in IVH. As a result, we recovered more than 80% of the endotoxin from the diluted IVH solution.
