To confirm the stability of tablets and capsules in one-dose packaging dispensation, we studied changes in three different storage conditions regarding the external appearance, weight, hardness, disintegration time and contents.
A change in the external appearance change was observed in two medicines under severe (temperature: 30°C), RH (relative humidity: 75%) one-dose package and naked conditions. Changes were in medicines in which the naked eye could not detect any changes regarding the color for 3 medicines. A weight change was observed in tablets made in one medicine. The hardness of the Lorazepam was found to decline by about 50% in severe conditions. A decline in the disintegration time was seen in Lisuride Maleate after 24 hours with (temperature: 26-32°C, RH: 43-70%). On the other hand, the Same disintesation time increased in severe condition. Change were seen regarding ofthe 5 medicines. A decline of about 50% was observed in Serrapeptase in under severe conditions. Based on the above findings the stability of medicines should therfore be carefully monitored when using one-dose packaging
