1-(2-Tetrahydrofuryl)-5-Flurouracilを主薬とする制癌剤について
1978 年 4 巻 2 号 p. 52-55
詳細
1978 年 4 巻 2 号 p. 52-55
In preparation for determination of bioavailability of drugs, in vitro disintegration test and dissolution test were conducted on 7 brands of oral anticancer agents containing 1-(2-tetra hydrofuryl)-5-fluorouracil, so as to compare their equivalency. Disintegration test was carried out in conformity with J. P. IX and dissolution test was made with sartorius solubility simulator. Three test fluids were used:(1) 1st fluid (artificially prepared gastric solution, pH 1.2);(2) 2nd fluid (artificially prepared intestinal solution, pH 7. 5);(3) water (pH 5. 6). Significant difference (not less than 5 %) of the disintegration time was observed among brands and test fluids; as for 50 % dissolution time, significant difference (not less than 5%) was observed among brands and not among test fluids.
