総合消化酵素製剤中の酵素の溶出性と安定性 (2)

抄録

Digestive activity, dissolution and stability of enzyme ingredients were compared among 4 commercial products (SV, EX, BE and FE) of multiple digestive enzyme Capsules. 1) Amylase: Gastric-soluble pellets of FE showed a strong and stable digestive activity in broad pH range, but enteric-soluble pellets had a weak activity. Gastric-and enteric-soluble pellets of 3 other products showed an equal digestive activity, but alkaline amylase activity of SV and EX became inactive in acidic solution. 2) Protease: Gastric-soluble pellets of BE and enteric-soluble pellets of FE had weaker digestive activity, and all other products had an equally strong digestive activity and stability. 3) Lipase: Gastric-soluble pellets of FE showed a strong and stable activity in broad acidic area, and digestive activity of entericsoluble pellets was rated in the order of EX>SV=BE>FE. Stability of lipase of 4 products lowered in proportion to increase in pH value of alkaline solution, but the strong lipase activity of the 4 products persisted for a long time in a weak acidic solution. 4) Cellulose: Cellulose, contained in only gastric-soluble pellets of 4 products, showed an equal digestive activity and stability, except for strong digestive activity of BE and excellent stability of FE. 5) Dissolution of enzymes contained in enteric coated pellets: FE showed excellent dissolution and BE had less dissolution of some pellets. Dissolution of enzymes from some enteric coated pellets of EX was noted in acidic solution. The above findings indicated that BE and EX contain heterogeneous pellets.