Abstract
Gefarnate is geranyl farnesylacetate which is easily oxidizable and is prone to hydrolysis owing to the presence of 5 double bonds in the molecule. Therefore, highly advanced technique is required to prepare the product. Some qualitative differences may occur among the products depending on manufacturing techniques.
The quality of the products on the market of 9 manufacturers was compared in terms of dissolution rate, content uniformity, peroxide value and hydrolysis rate. Two products showed excellent results, but there were a few products which were very questionable in view of their dissolution rate, content uniformity and peroxide value.
