Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
Analysis of Weight, Disintegration Time and Hardness of Commercial Tablets and Capsules
AKIRA KOSHIROKATSUYOSHI FUJIMOTOKEIZO ISHIMOTO
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1980 Volume 6 Issue 3 Pages 166-172

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Abstract
Statistical study on weight, disintegration time and hardness was carried out on 170 kinds of commercial tablets (uncoated, sugar-and film-coated) and capsules. 1. Significant differences in the distribution of weight, disintegration time and hardness were observed among the dosage forms. 2. The coefficients of weight variation was extremely small but those of disintegration time and hardness varied widely. 3. The coefficients of determination (r2) on the correlation of hardness-disintegration time, weight-hardness and weight-disintegration time were all smaller than 0.5 and, therefore, it was considered that there is no correlation among the above three variations.
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