Interaction of Ascorbic Acid Granules with Adjuvant Drugs

Abstract

Change in appearance, potency and weight increase of ascorbic acid granules (Hicee) in the presence of 74 adjuvant drugs was investigated. When combined with adjuvant drugs containing metal, potency of ascorbic acid was lowered. It was suggested in the study on weight increase that moisture content is closely related with potency. In the test by thinlayer chromatography it was found that 4-methylaminoantipyrine was detected when ascorbic acid was combined with sulpyrin.