抄録
The concentrations of phenytoin, phenobarbital and prlmidone in plasma and saliva were determined. The result obtained by MARKIT method showed a good agreement with that by EMIT method, with the exception of the determination of low concentration of phenytoin in saliva. However, when the phenytoin concentration in plasma was above 2.0μg/ ml, it was possible to determine salivary phenytoin in low concentration by adding one of the following operations to EMIT method: 1) concentration determined by CP 1000 and then calculated from the half-dose standard curve of DPH-calibrators diluted by DPH negative human serum; 2) concentration determined by CP 5000 in similar test method of plasma sample. In both operations, the salivary dilution omitted from EMIT method.
