Abstract
It was investigated in order to predict the pH-dependent incompatibility (haze formation, precipitation etc.) of the injection in infusion solution. 3 kinds of injections diluted to 500 ml with distilled water and 35 kinds of infusion solutions (500 ml) were titrated with 0.1 N HCl and 0.1 N NaOH, respectively. Then the pH characteristic curve was defined as a continuous curve that consists of 2 kinds of pH titration curves (with 0.1 N HCl and 0.1 N NaOH). Positive or negative equivalent values (that represent acidity or alkalinity) of the injection and infusion solution were determined by using the pH characteristic curve. pH of the admixture was determined by using the pH characteristic curve in which the other equivalent value was plotted. The appearance change of injection in infusion solution was predicted by comparing the estimated pH and the incompatible pH of the admixture was determined preliminarily.
