抄録
We performed comparative studies on the adsorption of recombinant factor VIII (rF VIII) to various infusion sets and various inline filters. The rFVIII used in this study was Kogenate® (Bayer). The infusion devices included the polyvinylchloride (PVC-A) infusion set, and the polyvinylchloride (PVC-B) and polybutadiene (PB) pump infusion sets. Regarding the inline filters, we used degenerated polysulfon (DPS), polyethersulfon (PES) and degenerated polyethersulfon (DPES) filters. After 250IU of rFVIII was dissolved in 250mL of normal saline in a polypropylene bag, the infusion was then allowed to drip through the infusion devices (1mL/min). The rFVIII activity of the infusion through the infusion sets was temporarily decreased at 0.25 hours. The recovery rate of the rFVIII activity after dripping through the infusion sets were 103.6% for PB, 90.6% for PVC-B, and 83.7% for PVC-A. The recovery rate of the rFVIII activity after dripping through PVC-A and each inline filter was 84.1% for DPS, 59.8% for PES, 50.9% for DPES. The adsorption of rFVIII to various infusion sets and inline filters was confirmed to depend on the quality of the materials. As a result, the adsorption for PB was thus found to be much less than that for the PVC-A and PVC-B infusion sets.
The adsorption per unit area for each inline filter was DPS (-0.1IU/cm2). PES (1.48IU/cm2), and DPES (8.21IU/cm2). Consequently, the adsorption for DPS and PES was found to be dramatically less than for DPES.
