Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
Drug Loss after Injection into a Polyvinyl Chloride Tube, which Contains Tris (2-ethylhexyl) Trimellitate as a Plasticizer
Mutsuko TanakaKenji KawanoTakehisa Hanawa
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Keywords: PVC, TOTM, DEHP, drug loss, sorption
JOURNAL FREE ACCESS

2003 Volume 29 Issue 6 Pages 711-714

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Abstract
Tris (2-ethylhexyl) trimellitate (TOTM) and Di (2-ethylhexyl) phthalate (DEHP) are plasticizers of Polyvinyl Chloride (PVC). We compared PVC-TOTM tubes and PVC-DEHP tubes regarding the loss of isosorbide dinetrate (ISDN) during drip infusion. The ISDN concentration was determined using HPLC. When ISDN injection (0. 5mg/mL) was passed through. a PVC-TOTM tube or a PVC-DEHP tube 90cm in length and 0.21cm inside diameter at a flow rate of 5. OmL/hr at 24°C, the ISDN concentrations were reduced to about 33. 1 % or 33.6% after lhr respectively, and gradually returned to the initial level with time. A liner relation was observed between the amount of ISDN sorbed to the PVC-TOTM tube and the equilibrium concentration of the diluted solution within the10-40μg/mL range. The same relationship was also observed in a PVC-DEHP tube. The results suggest that the ISDN loss from the solution occur through the mechanism of partition and diffusion to the PVC-TOTM tube.
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