Abstract
We prepared rapidly disintegrating tablets containing camostat mesilate to prevent the occurrence of stomatitis during cancer chemotherapy. The tablets were made by the direct compression of a moistened powder mixture of camostat mesilate, D-mannitol, flavoring agent, polyvinylpyrrolidone K30 and 25% ethanol aqueous solution. The tablets retained sufficient mechanical strength and rapidly disintegrated after being placed in the mouth. Moreover, the bitterness of camostat was reduced by the flavoring agent. The amounts of camostat retained in the mouth after the administration of the tablets to healthy subjects were much larger than those in the case of a gargling. These rapidly disintegrating tablets are therefore expected to be a more effective preparation than gargling to prevent the occurrence of stomatitis during cancer chemotherapy.
