抄録
Having confirmed the augmentative effects of choline and betaine on the regeneration of the visual purple in previous experiments, the author studied the effects of creatine and creatinine, chemically, closely related to choline and betaine, and also sodium monoiodoacetate which plays as important role in the metabolism of creatine.
In the first series of experiments, the colours of the retinae isolated from the dark adapted animals to which some creatine, creatinine or monoiodoacetate had been previously injected, were examined by means of Garten's table and compared with those of the control animals. The results showed that the retinae taken from the test animals were paler in colour than those of the controls.
In the second series of experiments, the concentrations of the visual purple of test and control animals were measured and compared by means of a photoelectric spectrophotometer. The results showed that creatine, creatinine, and sodium monoiodoacetate inhibited the regeneration of the visual purple. The effects were found to be considerably stronger than that of cocaine.
