ION TRANSPORT AND OXYGEN UPTAKE IN SARTORIUS MUSCLE, WITH PARTICULAR REFERENCE TO THE EFFECT OF DNP
1962 年 12 巻 6 号 p. 561-572
詳細
1962 年 12 巻 6 号 p. 561-572
1. The Na and K content of the sartorius muscle of toads treated with various metabolic inhibitors was measured. In IAA the muscle gains Na and loses K, the gain of Na being nearly equal to loss of K.
2. The muscle also loses K in DNP, but it either loses K or accumulates Za, depending on the concentration, temperature and soaking time. Therefore in the muscle poisoned with DNP the Na secretory machanism operates quite independently from K uptake.
3. The oxygen uptake is increased by several folds in DNP-treated muscles compared with that in the control. At 15°C the oxygen uptake shows the maximum with a concentration of 0.025mM, while at 25°C the maximum lies at 0.05mM. The oxygen uptake is not increased in parallel with the facilitation of the Na secretion.
4. The membrane potential of the muscle fibre treated with inhibitors is reduced with time and in parallel with the decrease in K concentration inside the muscle fiber. There is a good correlation between the membrane potential and the K content of the muscle, suggesting that the former is determined primarily by the latter.
