Abstract
The thyroid-creatinuria induced by non-toxic doses of thyroid was found to be due to the manifestation of glucocorticoids action.It was difficult to be induced in the absence of adrenal glands and a supply of small amount of cortisone made it reappear.The increased utilization of liver glycogen by thyroid hormone seemed to be the necessary condition of the induction of the glucocorticoids action.Both the thyroid-and cortisone-creatinuria could be prevented by increasing the amount of food intake.These creatinuria, even if marked, were accompanied by only slight increase in the urinary output of guanidinoacetic acid, the immediate precursor of creatine.This was contrary to the case in which exogenous creatine was administered for induction of creatinuria: a very marked increase in guanidinoacetic acid output with slight creatinuria. Thus the possibility of increased synthesis of creatine as the cause of the creatinuria was discussed against the traditional view of the loss of muscular creatine as a wasteful creatinuria.
