抄録
1. The administration of synthetic lysine vasopressin (100 and 40 mU per 100g, i. p.) caused a marked decrease in the metabolic rate in fasted rats. Synthetic oxytocin (400 mU per 100g, i. p.) had no effect.
2. The administration of hypertonic sodium chloride solution (2ml per 100g, per os) caused a slight but significantdecrease in the metabolic rate in fasted rats. Chronic administration of 2 per cent sodium chloride solution for 7 days did not show any change in the metabolic rate.
3. In sugar administered rats the decrease in the oxygen consumption produced by vasopressin was associated with an elevation of the RQ. In rats with high RQ values exceeding 0.900 the suppressive effect of vasopressin was not observed.
4. The calorigenic effect of norepinephrine was entirely abolished by treatment with vasopressin.
5. In alloxan diabetic rats the suppressive effect of vasopressin was also observed, though the metabolic rate wasextremely low in these animals.
6. The results suggest that vasopressinexhibits its effect on the metabolic rate by suppressing fat utilization as metabolic fuel.
