ROLE OF SEROTONIN IN THE THERMOGENESIS IN RAT BROWN ADIPOSE TISSUE

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Serotonin was effective in vitro in stimulating the release of FFA by brown adipose tissue and the increase of FFA release was accompanied by a similar increment of the oxygen consumption of the tissue. On the other hand, serotonin had no influence on the respiration of liver and brain slices.
The increase in oxygen consumption of brown adipose tissue which was induced by serotonin and epinephrine was well correlated with the amount of FFA reesterified
The effects of serotonin on FFA release and oxygen consumption were completely abolished by reserpinization or significantly diminished by denervation. However, the effects of epinephrine or theophylline on brown adipose tissue were not influenced by these treatments.
The effects of norepinephrine was markedly potentiated by the addition of serotonin which by itself was ineffective at the amount used.
From the results it was inferred that catecholamines are of primary importance in the regulation of active thermogenesis in the brown adipose tissue, while serotonin is likely to play rather subsidiary role only in the presence of catecholamines.