Abstract
The effects of tetrodotoxin on the electrical components slow potential and spikes have been studied in the crab cardiac ganglion cell.
1. The slow potential was periodically produced, and it initiated a short high-frequency train of spikes in the axon.
2. The spikes were abolished selectively by tetrodotoxin at extremely low concentrations, but the slow potential remained, indicating that the slow potential and the spikes are produced by different mechanisms.
3. Four large cells in the anterior part of the ganglionic trunk produced slow potentials synchronously, which did not result only from the electrotonic spread of the slow potential in a single cell.
