SOME FACTORS INFLUENCING THE PENETRATION OF P³² INTO NERVOUS TISSUE

抄録

The penetration of P³² into nervous tissue was studied and the results may be summarized as follows.
1) The intensity (penetration quantity) increases within three hours, and continues to increase with the passing of time.
2) The uptake of P³² by nerves has been studied at temperatures ranging from-2°C. to 35°C. Calculated in accordance with Arrhenius's equation, the activation energy of the transfer process, μ, was about 8500 calories in experiment I and 5060 calories in experiment II. The magnitude of this value indicates that the transfer process is physical rather than chemical in nature.
3) By addition of various drugs the penetration was almost inhibited.
4) The uptake of P³² by the trichlor acetic-acid-soluble portion of nerve is much greater than that by the insoluble portion.
5) The transferring of P³² seems to take place by diffusion.