Effbcts of β-Endorphin, Thyrotropin-releasing Hormone and Cholecystokinin On Body Shaking Behayior in Rats

抄録

Effects of intracerebroventricular administration of β-endorphin, thyrotropin-releasing hormone (TRH), cholecystokinin octapeptide (CCK-8), non-sulfated CCK-8 (CCK-8-NS) and caerulein on body shaking behavior were observed in rats. CCK-8 and its related peptides produced only a small increase in the number of body shakes, while TRH had the striking effect of stimulating body shakes, this increase being markedly suppressed by simultaneous administration of β-endorphin. Moreover, the suppressive effect of β-endorphin on TRH-induced body shakes was antagonized by simultaneous administration of caerulein and CCK-8. The body shakes induced by ice-water immersion were also reduced by β-endorphin, this β-endorphin effect being partly antagonized by caerulein and CCK-8.