Sulbenicillin-induced Kaliuresis in Man

抄録

The mechanism of kaliuresis induced by massive antibiotic administration was studied using α-sulfobenzyl penicillin (SBPC). In experimental group (n=8), urinary electrolytes excretion were compared between following the infusion of 10g SBPC in 200ml water at a constant rate and following the infusion of 48mmol of NaCl (equal to that contained in 10g SBPC) in 200ml water. For the control group, 96mmol NaCl in 400ml water was infused (n=5). In the experimental group, urinary Na (UNaV) and urinary K excretion (UKV) increased relative to the control period. In the control group, UKV was not increased although UNaV was increased (p<0.05). UKV following SBPC infusion was correlated with UNaV (p<0.05) and urinary SBPC excretion (p<0.05). The ratio of urinary anion gap to urinary cation [1-{urinary Cl concentration/(urinary Na concentration+ urinary K concentration)}] was significantly increased following SBPC infusion (p<0.005) but not in the control group. This increase in anion gap is possibly due to urinary SBPC, which will be ionized over 90% as nonreabsorbable anion in maximally acidic urine. We conclude that the kaliuresis induced by massive SBPC administration in man is probably caused by the nonreabsorbable anion effect of SBPC itself.