Cyclosporin A therapy is effective to the decrease of proteinuria in IgA nephropathy -a case of report-

Abstract

  A eleven-years old girl was detected as asymptomatic hematuria and proteinuria at the mass urine screening for school children. Biopsied renal pathology was IgA nephropathy showing diffuse mesangial proliferative glomerulonephritis on light microscopy. She received the following diffrent three therapies every two months; first therapy: combined therapy of intravenous methylpredonisolon pulse and heparin, second therapy: combined therapy of oral predonisolon, mizolibin and wafarin, third therapy: combined therapy of oral predonisolon, cyclosporin A and warfarin. The effect of reduced proteinuria was evaluated in these three different therapies using the ratio of proteinuria at the first morning urine⁄ urine creatinine and 24-hour urine protein excretion. A rapid decrease of proteinuria was obtained in the last therapy as compared to the other two therapies. Our results suggest in our patients that the decrease of proteinuria is due to the other effect of cyclosporin A against the hyperpermeability of protein in the glomerulus in addition to immunosppressive effect.