Abstract
We assayed concentrations of the microemulsion formulation of Cyclosporine, and estimated the pharmacokinetic parameters using concentration time profiles and correlation of the parameters with the area under the concentration curve (AUC) and coefficient of variation (CV%) in 16 children with idiopathic nephrotic syndrome. C0 and C6 were well correlated with AUC based on Pk0-12. Most cases showed the Tmax was from 1 hour to 2 hours, some cases of Cmax were indistinct and Tmax varied widely. C2 is suitable as an index for monitoring more than C0 in adult transplant patients. However our results demonstrate that C0 and C6 have good correlation compared with C2, and they may provide a useful monitoring index. Furthermore, we need to conduct further investigations because of the peculiarity of some pharmacokinetic cases
