Abstract
In this report, we described the case of a nineteen years-old-man with obesity-related focal segmental glomerulosclerosis. He was suffering from hypomelanosis of Ito, mental retardation and symptomatic localization-related epilepsy. Mild proteinuria was detected during a follow-up screening when his body weight was 69.0kg at twelve years old. At sixteen years old, the following were the clinical findings body weight, 98.0kg; height, 163.0cm; body mass index, BMI 36.9kg/m3;Blood pressure, 144/88mmHg, and urinary protein level, 1.5g/day. The administration of an angiotensin-converting enzyme (ACE) inhibitor was then started. For obesity, he was given guidance on a dietary regimen, but he still gained weight. The initial renal biopsy was performed when he was eighteen years old, weighing 107.7kg, 164.0cm tall, with a BMI of 40.0, and with a urinary protein level, 3.9g/day. Renal biopsy samples showed the swelling and segmental sclerosis of glomeruli on light microscopy;therefore, he was dig obesity-related focal segmental glomerulosclerosis. He was treated with the ACE inhibitor; to decrease his weight, he underwent a dietary regimen and exercise therapy. Obesity-related focal segmental glomerulosclerosis is rarely encountered in children, but obese children with proteinuria may be predisposed to this disease.
