Genetic analysis and genetic counseling for hereditary kidney disease

Abstract

The kidney is an extremely complex organ derived from the intermediate mesoderm, and the development and maintenance of its function involve a multitude of genes. Due to abnormalities in these genes, various types of hereditary kidney diseases can occur, resulting in a wide range of genetic kidney disorders. Advances in genome analysis technology in recent years have enabled the diagnosis of many patients with hereditary kidney diseases, leading to the identification of new causative genes. In the field of kidney disease management, genomic data is increasingly utilized in medical practice, promoting the advancement of genomic medicine. However, the promotion of genomic medicine is recommended to be accompanied by genetic counseling. To advance genomic medicine in the field of kidney diseases, it is essential to establish a collaborative framework involving nephrologists, clinical geneticists, certified genetic counselors, basic researchers, and professionals from a wide range of fields.