A 49-year-old female underwent breast reconstruction with a silicone breast implant (SBI) for left breast cancer. During the postoperative course, she was diagnosed as psoriasis vulgaris and received human monoclonal antibody (brodalumab) treatment. She was also diagnosed with SBI rupture twice. She received replacement of the SBI for the first rupture and replacement by free rectus abdominis myocutaneous flap for the second rupture. Although she had been taking human monoclonal antibody for more than 1 year, after replacement by autologous tissue, she did not require further antibody treatment because psoriasis vulgaris was resolved. The increased severity of psoriasis vulgaris coincided with the time the implants were inserted. Therefore, an association was suspected between psoriasis vulgaris and SBI rupture. When autoimmune-mediated disease develops or worsens after SBI reconstruction, the SBI is a possible cause.
