We have developed the fluorescence diagnostic apparatus of oral lesion. In this study, we analyzed autofluorescence of SCC and leukoplakia. Both cases of SCC and leuk oplakia, we found two fluorescence peaks. In case of SCC, a major peak was at 628 nm and a smaller peak was at 668 nm. As regard to intensity, the maximal intensity of SCC was 18 times stronger than that of normal oral mucosa. In case of leukoplakia, a major peak was at 658 nm and smaller peak was at 627 nm. The maximal intensity of leukoplakia was five times stronger than that of normal oral mucosa. The results suggested that the autofluorescence diagnosis of oral lesion would be possible by new fluorescence diagnostic apparatus.
