The Effect of Piezoeloctric Film on the Bone Regeneration in Rats
1992 Volume 36 Issue 2 Pages 419-433
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1992 Volume 36 Issue 2 Pages 419-433
This study was designed to investigate the effect of piezoelectric film as irregular current source on the bone regeneration in rats. An electrical current with irregularitis in both amplitude and frequency produced by a sheet of piezoelectric film was used. The subjects included sixty Wistar-strain male rats with an average age of 13 to 15 weeks, which were then randomly divided into 3 test groups. Under general anaesthesia, a hole of 2.0 mm in diameter was drilled in the right femoral diaphysis of each rat in all three groups. In the control group, the hole remained uncovered. In Group A, non-poling VDF/TrFE film (10×5 mm) covered over the hole. In Group B, the hole was covered by piezoelectric film (poling VDF/TrFE film, 10×5 mm), which generated a maximum average voltage of+1, 531-1, 612 mV when the rat moved freely. Time sequence of observation were 1st, 2nd, 3rd and 4th week with Tetracycline and Calcein bone labelling. Microscopic histopathological observations were made under three conditions: noumal light and fluorecent light, and contact microradiograph.
The results were as follows:
1. During first week, the outline of femur had been rapidly repaired to normal in Group A, yet by the later stage the mineralization of the bone in Group A was delayed more than the control group.
2. In Group B, however by the first week, it was observed that the outline of femur had not only been repaired fastest, but the bone had also mineralized more rapidly than the other two groups.
3. By the early stage, cancellous bone and osteoid formation were observed under VDF/TrFE film in Group. B, whereas in the other groups there was a delay in the formation of cancellous bone.
From the above results, it appeared that piezoelectric film behaved nearly as same as the SGP current, and effected bone formation. It can be stated that the poling VDF/TrFE film accelerated new bone formation both gualitatively and quantitatively, and that this film might serve as an effective method for the dental implants as well as it might also be applied for periodontal and/or surgical bone defect.
