Abstract
To study what kinds of sugar residues are involved in the specific adherence of Candida, several kinds of sugars were coverently bound to the glass slides either by coupling p-aminophenyl-o-glycosides or amino sugars to carboxyl methylene group of glyoxylic acid conjugated glass slides, and the adherence of Candida albicans andC. tropicalisto these immobilized sugars were measured.
C. albicansadhered to these glass slides with specific profiles, and the number of adherent cells were significantly higher to glass slides containing mannose-, mannosamine-, galactosamine-and fucose-residue than to control glass slides. TheC. albicansadherence to these sugar-immobilized glass was inhibited by the presence of monosaccharides with similar configuration to immobilized ones. These results, taken together, suggested that mannose-, mannosamine-, galactosamine- and fucose-residues are involved in the specific adherence ofC. albicansthrough lectinlike interaction.
In contrast, C. tropicalisshowed the specific adherence only to glass slides containing glucosamine.
