抄録
Patients under the treatment with major tranquilizer occasionary suffer from malocclusion due to the extrapyramidal symptom which is one of the side effects of the drug. The author propose to call this symptom as “drug induced malocclusion (DIMO)” and present here the two cases. Case 1 was a 24-year-old female schizophrenic patient. Her occlusion began to be wrong before one year after taking major tranquilizer, that is haloperidol. She was able to remember her past normal occlusion. Despite of her severe open bite, she did not worry and complained about it. She denied the treatment.
The second DIMO case was a 47-year-old male alcoholic dependent patient. His occlusion became wrong after the priscription of propericyazine before one week. Though his malocclusion was lesser than former case, he complained masticatory disturbance strongly. He asked me the treatment eagerly. The treatment by means of occlusal splint was performed and his occlusion was restored to normal after 4 months. To compair the attitudes toward DIMO between the cases, the bizzare attitude toward DIMO was remarkable in the first schizophrenic case.
In order to confirm the existence of bizzare attitude toward DIMO in schizophrenic patient, two groups of DIMO were compaired. The group 1 was composed of 14 schizophrenic patients and the group 2 9 patients with other mental disorders, that was alcoholic dependence, depression, and so on. The results clearly showed the difference between two groups. All patients in group 2 recognized accurately their DIMO, complained about it and desired the treatment. On the other hand, in the schizophrenic group 1, four patients did not recognized their DIMO, half of the patients did not complained about it, and only 5 patients desired its treatment. It was suspected that schizophrenic patients' bizzare recognition and reaction toward the DIMO were due to their cognitive deficit.
