新しい抗うつ薬tianeptineの行動薬理学的検討

抄録

Tianeptine is a novel antidepressant which uniquely facilitates 5 -hydroxytryptamine (5-HT) re-uptake. When given in a dose of 10 mg/kg to rats pretreated with phenelzine (50 mg/kg), it markedly reduced the frequency of wet-dog shakes (WDS) evoked by tryptophan (100 mg/kg) given 30 min later. This effect of tianeptine was opposite to that of paroxetine, a selective 5 -HT re-uptake inhibitor, which greatly increased thetryptophaninduced WDS. On the other hand, repeated administration of tianeptine for 4 weeksincreased the WDS induced by tryptophan whereas single tianeptine administration produced the opposite effect. Chronic treatment of paroxetine also increased the tryptophan-induced WDSalthough the effect was attenuated. When behavioural response was tested 24 hours after tianeptine or paroxetine injection, chronic treatment of both drugs tended to increase the tryptophan-induced WDS but did not affect the WDS evoked by DOI, a selective 5 -HT₂receptor antagonist.