三叉神経電気刺激による事象関連電位に関する研究

実験的疼痛に対するP300成分の解析

抄録

We measured event related potential (ERP) by applying strong and weak electric stimulations to the lips of 11 healtyh adult male subjects to quantitatively analyze the relation between the target stimulation wave form component in relation to the subjective pain sensation.
1) Regarding the target stimulation wave form component, both the group highly sensitive to pain (high sensitivity group) and the group less sensitive to pain (low sensitive group) demonstrated a common waveform component of N100 and P300 against the Fz-and Pz-led waveforms, and regarding the standard stimulation waveform component, the common waveform component of N100 and P250 against the Fz-and Pz-led waveforms. The P300 component in the target stimulation waveform was the ERP component while the P250 component of the standard stimulation wave form was the pain-related late positive component.
2) No significant difference was observed in Fz-and Pz-led waveforms between the high sensitivity group and the low sensitivity group at P300 latency of the target stimulation waveform, but a significant amplitude increase was indicated in both the Fz-and Pz-led waveforms in the high sensitivity group (p<0.05) compared with the low sensitivity group.
3) Though no significant difference was observed in the Fz-and Pz-led waveforms between the two groups at P250 latency of the standard stimulation waveforms, there was a significant increase in the N100 P250 amplitude of Fz-led waveform (p<0.05) in the high sensitivity group as compared with the low sensitivity group. Although there was no statistically significant difference in the Pz-led waveforms, the high sensitivity group indicated a tendency of increase in amplitude (p<0.1).
4) N100-300 amplitudes may permit the objective determination of the fear, anticipation and anxiety of pain.