難治性歯周症患者における局所病変と全身の反応

主に血行動態反応とCoenzyme Q₁₀動態, その治療への貢献

抄録

Systemic circulatory and hemodynamical examinations were performed on intractable periodontal disease patients (PDP) with high PDI (periodontal disease index) and SRPS (self-rating periodontal score). Among PDP, abnormal findings on chest X-ray, ECG, and/or ECG with tilting test were sometimes found.
Those who had abnormal findings showed poorer scores on PDI & SRPS than those with normal findings. Hemodynamical feature in PDP resembled the hypokinetic type of dysdynamic syndrome. The reason was considered to be poorer inotropic action of the cardiac sympathetic nerve. Low serum coenzyme Q₁₀ levels were observed in PDP. Most PDP have some functional hemodynamical or circulatory diseases, therefore, for diagnosis systemic examinations should be performed in addition to oral pathology. After the administration of coenzyme Q₁₀ in PDP the PDI, SRPS, serum coenzyme Q₁₀ levels and hemodynamics improved simultaneously. It is considered that coenzyme Q₁₀ has some potential to cure intractable periodontal disease.