Rapidly progressing nuclear protein in testis carcinoma of the lung in a young woman that was treated with chemotherapy plus immune checkpoint inhibitors: A case report

Abstract

A 31-year-old woman presented to her local clinic with wheezing and coughing as the chief complaint. She was diagnosed with squamous cell lung cancer (cT2aN2M1c, Stage ⅣB) based on transbronchial biopsy and positron emission tomography/computed tomography, and was found to be positive for the WHSC1L1 (NSD3)-NUTM1 fusion gene. The patient was urgently admitted to our hospital due to worsening metastatic bone pain and started combination therapy with carboplatin, albumin-bound paclitaxel, and pembrolizumab. The tumor shrank for a while, but before the second course of treatment was started, it grew again and the patient’s general condition deteriorated, so palliative treatment was commenced instead. One month after treatment began, the patient died. Nuclear protein in testis carcinoma of the lung has a poor prognosis, and our report of this case includes a literature review.