Annals of the Japanese Respiratory Society
Online ISSN : 2186-5884
Print ISSN : 2186-5876
ISSN-L : 2186-5876
Case Reports
A case of drug-induced lung injury caused by pegylated liposomal doxorubicin
Yuri Shimada Tomoyoshi ItohSoichiro YoshimuraFukumichi IshiyamaTsuyoshi HattoriYuya Inada
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2025 Volume 14 Issue 3 Pages 141-146

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Abstract

We present a case of drug-induced lung injury caused by pegylated liposomal doxorubicin in a 49-year-old woman. Pegylated liposomal doxorubicin was administered for the first time 72 days before she was hospitalized for left fallopian tube cancer. On hospitalization, she presented with dyspnea on exertion and cough. A chest computed tomography scan revealed ground-glass opacities predominantly in both upper lung fields with consolidation, traction bronchiectasis, and interlobular septal thickening. Consequently, drug-induced lung injury caused by pegylated liposomal doxorubicin was suspected, and subsequently administered steroid therapy resulted in an improvement in computed tomography findings. Thus, physicians should consider pegylated liposomal doxorubicin as a potential cause of drug-induced lung injury.

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© 2025 The Japanese Respiratory Society
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