2025 Volume 14 Issue 3 Pages 147-151
A 76-year-old man started treatment with apalutamide and degarelix for advanced prostate cancer. About 2 months later, the patient complained of cough and exertional dyspnea and visited our department. A computed tomography scan of the chest showed ground glass opacities with patchy distribution in both lungs. The shadows rapidly improved with suspension of both drugs and steroid pulse therapy. The drug-induced lymphocyte stimulation test (DLST) for apalutamide was found to be strongly positive, and the diagnosis of drug-induced lung injury was confirmed. We report a case of drug-induced lung injury due to apalutamide with a strong positive DLST.
