2025 Volume 14 Issue 4 Pages 190-194
Epipericardial fat necrosis (EFN) is a rare disease that presents with acute pleuritic pain. EFN is generally associated with a mildly elevated inflammatory response, and nodules are often present. Herein, we describe a case of EFN diagnosed with acute pleuritic pain, high inflammatory response, mediastinal mass shadow, and pleural effusion. Although pericardial fat necrosis is considered to be a rare disease, an increasing number of cases have been reported in recent years. EFN should be considered in patients with acute pleuritic pain even if they present with other symptoms such as mediastinal mass and high inflammatory response.