A New Quantitative Inhalation Apparatus for Small Animals

Abstract

We have invented a quantitative inhalation apparatus for small animals. Experimental ^99mTc-albumin inhalation in anesthetized guinea pigs revealed that the drug can be delivered efficiently by ultrasonic nebulizer to the lung with the aid of a volume-type respirator. Using this apparatus it was easy to monitor the airway pressure concomitantly with various hemodynamic parameters. It is now apparent that our new apparatus could be an inexpensive and effective tool for both physiological and pharmacological studies on experimental asthma in small animals.