Abstract
In a previous investigation we reported the usefulness of the measurement of adenosine deaminase (ADA) activity in patients with pleural effusion, and demonstrated that ADA activity in pleural effusion from patients with tuberculous pleuritis was significantly higher than that of patients with carcinomatous pleuritis.
In the present investigation we measured ADA activity in pleural effusion and peripheral serum from 30 male Japanese albino rabbits with experimentally-induced pleuritis.
1) Pleural effusion was obtained from rabbits injected with complete Freund's adjuvant(CFA), acetic acid or λ-carrageenin to the pleural cavities, while no effusion obtained from rabbits in saline was injected pleural cavities.
2) The mean value and standard deviations of ADA activity in pleural effusion induced by CFA was 78.85±39.01U/L, while that induced by 2% acetic acid and λ-carrageenin was 18.03±3.17U/L and 11.06±4.81U/L, respectively. There were significant differences between the former group (CFA) and the latter two groups (2% acetic acid and λ-carrageenin).
3) Serum ADA activity in these three groups did not show any significant changes before and after drug injection into the pleural cavity during 1 week observation period.
