Abstract
A 47-year-old man, admitted to the hospital because of epigastric pain, was suspected to have obstructive jaundice from chemical laboratory data. An abdominal CT scan disclosed a solid tumor, 8cm in diameter, with a distinct border in the body and tail of the pancreas. ERP showed a filling defect in the main pancreatic duct, suggestive of an intraductal tumor growth, and endoscopic biopsy of the duodenal papilla revealed moderately differentiated tubular adenocarcinoma. A total pancreatectomy was performed. Macroscopically the tumor showed an intraductal solid growth throughout the pancreas with pancreatic atrophy extended to the duodenal papilla. Histologically the tumor showed an acinar growth pattern which consisted of acidophilic tumor cells with fine granular PAS positive cytoplasm. Immnohistochemically the tumor cells were positive for amylase and α-1-antitrypsin. Accordingly intraductal and papillary variant of acinar cell carcinoma of the pancreas was diagnosed. We report this case as the 11th case in Japan.
