Abstract
A 69-year-old woman underwent partial resection of the jejunum for jejunal gastrointestinal stromal tumor (GIST) with multiple liver metastases in January 2000, and was treated with TACE, PEIT and RFA for the liver lesions. In July 2003, she started treatment with imatinib mesylate and was thereafter maintained in a stable disease state for more than 5 years. In April 2009, CT scan showed a 3cm in diameter new lesion in S6 of the liver. Four months later, CT scan showed progression of only the S6 lesion because dose escalation was not allowed due to a side effect. In October 2009, she underwent partial resection of the liver for localized progression of the S6 tumor. Adjuvant imatinib mesylate at a dose of 300mg/day was restarted and no progression has been detected for 14 months. Combined modality therapy with TACE, PEIT, RFA, imatinib mesylate and surgery for GIST with multiple liver metastases contributed long-term survival exceeding 10 years.
